研究成果 - 西田　基宏

Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

2025年05月15日

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Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

2025年05月15日

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Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

2025年02月20日

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TRPC6-Mediated Zn2+ Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells

Biomolecules    2025年02月12日

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Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate

Cells    2025年02月03日

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Cardiac remodeling: novel pathophysiological mechanisms and therapeutic strategies

The Journal of Biochemistry    2024年09月30日

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Supersulfide catabolism participates in maladaptive remodeling of cardiac cells

Journal of Pharmacological Sciences    2024年08月

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Sulfur metabolism as a new therapeutic target of heart failure

Journal of Pharmacological Sciences    2024年07月

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Inhibition of Drp1–Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation by Increasing Mitochondria–Lipid Droplet Contact

International Journal of Molecular Sciences    2024年05月17日

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Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17

2024年05月12日

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Extracellularly secreted cysteine derived from cystine regulates oxidative and electrophilic stress in HepG2 cells

Free Radical Research    2024年05月03日

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Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression

International Journal of Molecular Sciences    2024年02月18日

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Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation

Journal of Pharmacological Sciences    2024年02月

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Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

2023年10月19日

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Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction

Communications Biology    2023年05月12日

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In Vivo mRNA Hacking with Staple Oligomers Prevents Myocardial Hypertrophy

2023年04月18日

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Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis

International Journal of Molecular Sciences    2023年02月14日

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Drug repurposing for the treatment of COVID-19

Journal of Pharmacological Sciences    2022年07月

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A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia

Cells    2022年06月

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Long-Acting Thioredoxin Ameliorates Doxorubicin-Induced Cardiomyopathy via Its Anti-Oxidative and Anti-Inflammatory Action

Pharmaceutics    2022年03月03日

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Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer

International Journal of Molecular Sciences    2022年02月10日

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Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques

Nature Communications    2021年11月03日

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Cold Atmospheric Plasma Modification of Amyloid β

International Journal of Molecular Sciences    2021年03月18日

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TRPC Channels in Cardiac Plasticity

Cells    2020年02月17日

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Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity

Journal of Lipid and Atherosclerosis    2020年

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TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

Scientific Reports    2019年12月

ISSN： 2045-2322

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Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3-Nox2 protein complex

British Journal of Pharmacology    2019年06月26日

ISSN： 0007-1188

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Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Science Signaling    2019年06月25日

ISSN： 1945-0877

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TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

The FASEB Journal    2019年06月04日

ISSN： 0892-6638

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2-Oxo-histidine-containing dipeptides are functional oxidation products

The Journal of biological chemistry    2019年

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Mitochondrial dynamics in exercise physiology

Pflugers Archiv : European journal of physiology    2019年

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TRPC channels in exercise-mimetic therapy

Pflugers Archiv : European journal of physiology    2019年

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Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Science signaling    2018年

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Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

Biochemical and biophysical research communications    2018年

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Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells

Journal of pharmacological sciences    2018年

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Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling

Advances in microbial physiology    2018年

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TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes

The journal of physiological sciences : JPS    2018年

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TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy

Frontiers in pharmacology    2018年

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[Lifestyle Inspires Future Pharmacotherapy and Drug Discovery]

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan    2018年

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[New Strategies for Exercise-Mimetic Medication]

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan    2018年

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A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy

Journal of pharmacological sciences    2017年

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Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Nature communications    2017年

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Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells

Chemical research in toxicology    2017年

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MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts

Journal of the American Heart Association    2017年

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Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Pharmacology & therapeutics    2017年

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Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension

Pharmacological research    2017年

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Purinergic signaling in cardiovascular system

Nihon yakurigaku zasshi. Folia pharmacologica Japonica    2017年

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Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

Free radical biology & medicine    2017年

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Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology

Progress in biophysics and molecular biology    2017年

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Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

Frontiers in pharmacology    2017年

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TRPC3 Channels in Cardiac Fibrosis

Frontiers in cardiovascular medicine    2017年

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TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy

JCI insight    2017年

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TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Scientific reports    2017年

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Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

Scientific Reports    2016年

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Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Science signaling    2016年

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Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides

Archives of biochemistry and biophysics    2016年

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Redox signaling regulated by electrophiles and reactive sulfur species

Journal of clinical biochemistry and nutrition    2016年

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Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds

Molecular pharmacology    2016年

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Sustained βAR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner

Molecular endocrinology (Baltimore, Md.)    2016年

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TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation

The Biochemical journal    2016年

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TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

Scientific reports    2016年

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TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

Scientific reports    2016年

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Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases

The Journal of biological chemistry    2015年

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Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress

Chemical research in toxicology    2015年

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TRP Channels: Their Function and Potentiality as Drug Targets

2015年

ISBN： 9784431556510

[Bone and Calcium Research Update 2015. Basic mechanisms underlying calcium signaling and their biological potentiality]

Clinical calcium    2015年

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Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure

Cardiovascular research    2014年

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Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling

Journal of molecular and cellular cardiology    2014年

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[Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species]

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan    2014年

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Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels

Arteriosclerosis, thrombosis, and vascular biology    2013年

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Dual actions of ANP on endothelial permeability

BMC pharmacology & toxicology    2013年

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Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide

Nitric oxide : biology and chemistry    2013年

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GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Nature communications    2013年

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Redox control of cardiovascular homeostasis by angiotensin II

Current pharmaceutical design    2013年

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Regulation of redox signalling by an electrophilic cyclic nucleotide

Journal of biochemistry    2013年

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Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice

Biochemical and biophysical research communications    2013年

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[Chemical biology of hydrogen sulfide]

Nihon yakurigaku zasshi. Folia pharmacologica Japonica    2013年

DOI

[Function and role of transient receptor potential channels]

Clinical calcium    2013年

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[Regulation of redox homeostasis by hydrogen sulfide anion and its clinical application]

Seikagaku. The Journal of Japanese Biochemical Society    2013年

β-arrestin2 in infiltrated macrophages inhibits excessive inflammation after myocardial infarction

PloS one    2013年

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Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

Nature chemical biology    2012年

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Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways

The Journal of biological chemistry    2012年

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Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis

Biology open    2012年

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Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes

Mitochondrion    2012年

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Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel

Arteriosclerosis, thrombosis, and vascular biology    2011年

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Determining the activation of rho as an index of receptor coupling to G₁₂/₁₃ proteins

Methods in molecular biology (Clifton, N.J.)    2011年

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Dual signaling pathways of arterial constriction by extracellular uridine 5'-triphosphate in the rat

Journal of pharmacological sciences    2011年

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Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB

Proceedings of the National Academy of Sciences of the United States of America    2011年

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Mechanism of the cardioprotective effects of docetaxel pre-administration against adriamycin-induced cardiotoxicity

Journal of pharmacological sciences    2011年

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Regulation of Angiotensin II receptor signaling by cysteine modification of NF-κB

Nitric oxide : biology and chemistry    2011年

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Roles of heterotrimeric GTP-binding proteins in the progression of heart failure

Journal of pharmacological sciences    2011年

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TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts

Biochemical and biophysical research communications    2011年

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Ca2+ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cells

Journal of cell science    2010年

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Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart

Circulation research    2010年

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Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation

The Journal of biological chemistry    2010年

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Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition

The Journal of biological chemistry    2010年

DOI

[ Frontiers of Ca(2+) signaling~physiological and pathological roles of voltage-independent Ca(2+) channels]

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan    2010年

DOI

[Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC channels]

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan    2010年

DOI

[Molecular mechanism underlying the development of heart failure mediated by heterotrimeric G protein signaling]

Nihon yakurigaku zasshi. Folia pharmacologica Japonica    2010年

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[Pharmacological properties of novel TRPC channel inhibitors]

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan    2010年

DOI

[Regulation of cardiovascular functions by the phosphorylation of TRPC channels]

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan    2010年

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[Signal transduction in the development of vascular disease and new therapeutic strategy]

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan    2010年

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Amphotericin B-induced renal tubular cell injury is mediated by Na+ Influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2+ concentration

Antimicrobial agents and chemotherapy    2009年

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Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway

BMC pharmacology    2009年

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Regulation of cardiac hypertrophy by the formation of G protein-coupled receptor--TRPC channel protein complex

Nihon yakurigaku zasshi. Folia pharmacologica Japonica    2009年

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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

Proceedings of the National Academy of Sciences of the United States of America    2009年

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A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction

Journal of neurochemistry    2008年

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Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells

Biochemistry    2008年

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P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis

The EMBO journal    2008年

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Roles of TRP channels in the development of cardiac hypertrophy

Naunyn-Schmiedeberg's archives of pharmacology    2008年

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[TRPC]

Nihon yakurigaku zasshi. Folia pharmacologica Japonica    2008年

Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation

The Journal of biological chemistry    2007年

DOI

Transient receptor potential channels in Alzheimer's disease

Biochimica et biophysica acta    2007年

DOI

[TRPC channels and cardiac hypertrophy]

Seikagaku. The Journal of Japanese Biochemical Society    2007年

Blocker-resistant presynaptic voltage-dependent Ca2+ channels underlying glutamate release in mice nucleus tractus solitarii

Brain research    2006年

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Clathrin required for phosphorylation and internalization of beta2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2)

The Journal of biological chemistry    2006年

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Heterotrimeric G protein G alpha13-induced induction of cytokine mRNAs through two distinct pathways in cardiac fibroblasts

Journal of pharmacological sciences    2006年

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TRP channels: molecular diversity and physiological function

Microcirculation (New York, N.Y. : 1994)    2006年

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TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy

The EMBO journal    2006年

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Transient receptor potential channels in cardiovascular function and disease

Circulation research    2006年

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Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK

Cellular signalling    2005年

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Caveolae-independent activation of protein kinase A in rat neonatal myocytes

Journal of pharmacological sciences    2005年

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Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes

Physiological genomics    2005年

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G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes

The Journal of biological chemistry    2005年

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Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts

The Journal of biological chemistry    2005年

DOI

Mutations in EFHC1 cause juvenile myoclonic epilepsy

Nature genetics    2004年

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Novel real-time sensors to quantitatively assess in vivo inositol 1,4,5-trisphosphate production in intact cells

Chemistry & biology    2004年

DOI

Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes

The EMBO journal    2003年

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Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation

Molecular pharmacology    2003年

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Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel

The Journal of biological chemistry    2003年

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Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells

Free radical biology & medicine    2003年

DOI

TRP channels: formation of signal complex and regulation of cellular functions

Nihon yakurigaku zasshi. Folia pharmacologica Japonica    2003年

DOI

Activation mechanism of Gi and Go by reactive oxygen species

The Journal of biological chemistry    2002年

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Ca(2+) channel alpha(1B) subunit (Ca(V) 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system

Trends in cardiovascular medicine    2002年

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G beta gamma counteracts G alpha(q) signaling upon alpha(1)-adrenergic receptor stimulation

Biochemical and biophysical research communications    2002年

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Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy

Circulation research    2002年

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LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death

Molecular cell    2002年

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Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes

The Journal of experimental medicine    2002年

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